Alex Tedder was senior vice president and co-head of global and non-US large cap strategies at American Century Investments, where he managed £12.47 billion of assets and a team of 15.
He will assume responsibility from Peter Harrison for the global and international equities team's business management and strategic planning in June.
He will also lead the team and drive the development of the team's franchise.
Simon Webber will retain his investment focus, working with the team's global sector specialists to ensure that client portfolios benefit from the team's proven research capabilities and high-conviction idea generation.
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Peter Harrison, global head of equities, said: "I am delighted to welcome Alex to Schroders.
"He is a strong investor with 20 years' experience and is an excellent cultural fit with our existing global equities team, consisting of eight global sector specialists and two portfolio managers.
"Global equities is a priority growth area for Schroders.
"Together, Alex and Simon will drive our existing strong business forward and make it world class, enhancing our portfolio construction process and delivering performance for clients over the long term."